Predicting non-neutral missense mutations and their biochemical consequences using genome-scale homology modeling of human protein complexes
نویسندگان
چکیده
Computational methods are needed to differentiate the small fraction of missense mutations BLOCKIN BLOCKIN that BLOCKIN BLOCKIN contribute BLOCKIN BLOCKIN to BLOCKIN BLOCKIN disease BLOCKIN BLOCKIN by BLOCKIN BLOCKIN disrupting BLOCKIN BLOCKIN protein BLOCKIN BLOCKIN function BLOCKIN BLOCKIN from BLOCKIN BLOCKIN neutral BLOCKIN BLOCKIN variants. We describe several complementary methods using large-‐scale homology modeling of human protein complexes to detect non-‐neutral mutations. Importantly, unlike sequence conservation-‐based methods, this structure-‐based approach provides experimentally testable BLOCKIN
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